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AZD 1678

CAS No. 942137-41-9

AZD 1678( AZD1678 | AZD-1678 )

Catalog No. M16739 CAS No. 942137-41-9

AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD 1678
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.
  • Description
    AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4; shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM); inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8.Asthma Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AZD1678 | AZD-1678
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    942137-41-9
  • Formula Weight
    352.1614
  • Molecular Formula
    C11H8Cl2FN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=C(F)N=C2OC)=O
  • Chemical Name
    2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986.
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